Nutritional and Clinical Glycomics Research

Author: laurenmd (Page 8 of 9)

2008 Publications

Argov, N., S. Wachsmann-Hogiu, S.L. Freeman, T. Huser, C.B. Lebrilla, and J.B. German, Size-dependent lipid content in human milk fat globules.. J Agric Food Chem, 2008. 56(16): p. 7446-50.

Clowers, B.H., E.D. Dodds, R.R. Seipert, and C.B. Lebrilla, Dual polarity accurate mass calibration for electrospray ionization and matrix-assisted laser desorption ionization mass spec using maltooligosaccharides Anal Biochem, 2008. 381(2): p. 205-13.

Dodds, E.D., B.H. Clowers, P.J. Hagerman, and C.B. Lebrilla, Systematic characterization of high mass accuracy influence on false discovery and probability scoring in peptide mass fingerprinting, 2008. 372(2): p. 156-66.

German, J.B., S.L. Freeman, C.B. Lebrilla, and D.A. Mills, Human milk oligosaccharides- evolution, structures and bioselectivity as substrates for intestinal bacteria. Nestle Nutr Workshop Ser Pediatr Program, 2008. 62: p. 205-18; discussion 218-22.

Li, B., H.J. An, C. Kirmiz, C.B. Lebrilla, K.S. Lam, and S. Miyamoto, Glycoproteomic analyses of ovarian cancer cell lines and sera from ovarian cancer patients show distinct glycosylation changes in individual proteins. J Proteome Res, 2008. 7(9): p. 3776-88.

McJimpsey, E.L., W.M. Jackson, C.B. Lebrilla, H. Tobias, M.J. Bogan, E.E. Gard, M. Frank, and P.T. Steele, Parameters contributing to efficient ion generation in aerosol MALDI mass spectrometry. J Am Soc Mass Spectrom, 2008. 19(3): p. 315-24.

Ninonuevo, M.R., P.D. Perkins, J. Francis, L.M. Lamotte, R.G. LoCascio, S.L. Freeman, D.A. Mills, J.B. German, R. Grimm, and C.B. Lebrilla, Daily variations in oligosaccharides of human milk determined by microfluidic chips and mass spectrometry.. J Agric Food Chem, 2008. 56(2): p. 618-26.

Packer, N.H., C.W. von der Lieth, K.F. Aoki-Kinoshita, C.B. Lebrilla, J.C. Paulson, R. Raman, P. Rudd, R. Sasisekharan, N. Taniguchi, and W.S. York, Frontiers in glycomics- bioinformatics and biomarkers in disease. An NIH white paper prepared from discussions by the focus groups at a workshop on the NIH campus, Bethesda MD, (September 11-13, 2006). Proteomics, 2008. 8(1): p. 8-20.

Seipert, R.R., M. Barboza, M.R. Ninonuevo, R.G. LoCascio, D.A. Mills, S.L. Freeman, J.B. German, and C.B. Lebrilla, Analysis and quantitation of fructooligosaccharides using matrix-assisted laser desorption ionization Fourier transform ion cyclotron resonance mass spectrometry.. Anal Chem, 2008. 80(1): p. 159-65.

Seipert, R.R., E.D. Dodds, B.H. Clowers, S.M. Beecroft, J.B. German, and C.B. Lebrilla, Factors that influence fragmentation behavior of N-linked glycopeptide ions. Anal Chem, 2008. 80(10): p. 3684-92.

Sela, D.A., J. Chapman, A. Adeuya, J.H. Kim, F. Chen, T.R. Whitehead, A. Lapidus, D.S. Rokhsar, C.B. Lebrilla, J.B. German, N.P. Price, P.M. Richardson, and D.A. Mills, The genome sequence of Bifidobacterium longum subsp. infantis reveals adaptations for milk utilization within the infant microbiome.. Proc Natl Acad Sci U S A, 2008. 105(48): p. 18964-9.

Tao, N., E.J. DePeters, S. Freeman, J.B. German, R. Grimm, and C.B. Lebrilla, Bovine milk glycome.. J Dairy Sci, 2008. 91(10): p. 3768-78.

Williams, T.I., D.A. Saggese, K.L. Toups, J.L. Frahm, H.J. An, B. Li, C.B. Lebrilla, and D.C. Muddiman, Investigations with O-linked protein glycosylations by matrix-assisted laser desorption-ionization Fourier transform ion cyclotron resonance mass spectrometry. J Mass Spectrom, 2008. 43(9): p. 1215-23.

2009 Publications

An, H.J., S.R. Kronewitter, M.L. de Leoz, and C.B. Lebrilla, Glycomics and disease markers.. Curr Opin Chem Biol, 2009. 13(5-6): p. 601-7.

Barboza, M., D.A. Sela, C. Pirim, R.G. Locascio, S.L. Freeman, J.B. German, D.A. Mills, and C.B. Lebrilla, Glycoprofiling bifidobacterial consumption of galacto-oligosaccharides by mass spectrometry reveals strain-specific, preferential consumption of glycans Appl Environ Microbiol, 2009. 75(23): p. 7319-25.

Barile, D., N. Tao, C.B. Lebrilla, J.D. Coisson, M. Arlorio, and J.B. German, Permeate from cheese whey ultrafiltration is a source of milk oligosaccharides.. Int Dairy J, 2009. 19(9): p. 524-530.

Barkauskas, D.A., H.J. An, S.R. Kronewitter, M.L. de Leoz, H.K. Chew, R.W. de Vere White, G.S. Leiserowitz, S. Miyamoto, C.B. Lebrilla, and D.M. Rocke, Detecting glycan cancer biomarkers in serum samples using MALDI FT-ICR mass spectrometry data.Bioinformatics, 2009. 25(2): p. 251-7.

Barkauskas, D.A., S.R. Kronewitter, C.B. Lebrilla, and D.M. Rocke, Analysis of MALDI FT-ICR mass spectrometry data- a time series approach Anal Chim Acta, 2009. 648(2): p. 207-14.

Chu, C.S., M.R. Ninonuevo, B.H. Clowers, P.D. Perkins, H.J. An, H. Yin, K. Killeen, S. Miyamoto, R. Grimm, and C.B. Lebrilla, Profile of native N-linked glycan structures from human serum using high performance liquid chromatography on a microfluidic chip and time-of-flight mass spectrometry. Proteomics, 2009. 9(7): p. 1939-51.

Cooke, C.L., H.J. An, J. Kim, D.R. Canfield, J. Torres, C.B. Lebrilla, and J.V. Solnick, Modification of gastric mucin oligosaccharide expression in rhesus macaques after infection with Helicobacter pylori. Gastroenterology, 2009. 137(3): p. 1061-71, 1071 e1-8.

Dodds, E.D., R.R. Seipert, B.H. Clowers, J.B. German, and C.B. Lebrilla,Analytical performance of immobilized pronase for glycopeptide footprinting and implications for surpassing reductionist glycoproteomics. J Proteome Res, 2009. 8(2): p. 502-12.

Dodds, E.D., F. Tassone, P.J. Hagerman, and C.B. Lebrilla, Polymerase chain reaction, nuclease digestion, and mass spectrometry based assay for the trinucleotide repeat status of the fragile X mental retardation 1 gene. Anal Chem, 2009. 81(13): p. 5533-40.

Kronewitter, S.R., H.J. An, M.L. de Leoz, C.B. Lebrilla, S. Miyamoto, and G.S. Leiserowitz, The development of retrosynthetic glycan libraries to profile and classify the human serum N-linked glycome. Proteomics, 2009. 9(11): p. 2986-94.

Lebrilla, C.B. and H.J. An, The prospects of glycan biomarkers for the diagnosis of diseases.Mol Biosyst, 2009. 5(1): p. 17-20.

Lebrilla, C.B. and L.K. Mahal, Post-translation modifications. Curr Opin Chem Biol, 2009. 13(4): p. 373-4.

Li, B., H.J. An, J.L. Hedrick, and C.B. Lebrilla, Collision-induced dissociation tandem mass spectrometry for structural elucidation of glycans. Methods Mol Biol, 2009. 534: p. 133-45.

Li, B., H.J. An, J.L. Hedrick, and C.B. Lebrilla, Infrared multiphoton dissociation mass spectrometry for structural elucidation of oligosaccharides. Methods Mol Biol, 2009. 534: p. 23-35.

Locascio, R.G., M.R. Ninonuevo, S.R. Kronewitter, S.L. Freeman, J.B. German, C.B. Lebrilla, and D.A. Mills,A versatile and scalable strategy for glycoprofiling bifidobacterial consumption of human milk oligosaccharides. Microb Biotechnol, 2009. 2(3): p. 333-42.

Ninonuevo, M.R. and C.B. Lebrilla, Mass spectrometric methods for analysis of oligosaccharides in human milk Nutr Rev, 2009. 67 Suppl 2: p. S216-26.

Seipert, R.R., E.D. Dodds, and C.B. Lebrilla, Exploiting Differential Dissociation Chemistries of O-Linked Glycopeptide Ions for the Localization of Mucin-Type Protein Glycosylation J Proteome Res, 2009. 8(2): p. 493-501.

Tao, N., E.J. DePeters, J.B. German, R. Grimm, and C.B. Lebrilla, Variations in bovine milk oligosaccharides during early and middle lactation stages analyzed by high-performance liquid chromatography-chip mass spectrometry J Dairy Sci, 2009. 92(7): p. 2991-3001.

2010

An, H.J. and C.B. Lebrilla, A glycomics approach to the discovery of potential cancer biomarkersMethods Mol Biol, 2010. 600: p. 199-213.

Argov-Argaman, N., J.T. Smilowitz, D.A. Bricarello, M. Barboza, L. Lerno, J.W. Froehlich, H. Lee, A.M. Zivkovic, D.G. Lemay, S. Freeman, C.B. Lebrilla, A.N. Parikh, and J.B. German, Lactosomes- Structural and Compositional Classification of Unique Nanometer-Sized Protein Lipid Particles of Human Milk. J Agric Food Chem, 2010.

Barile, D., M. Marotta, C. Chu, R. Mehra, R. Grimm, C.B. Lebrilla, and J.B. German, Neutral and acidic oligosaccharides in Holstein-Friesian colostrum during the first 3 days of lactation measured by high performance liquid chromatography on a microfluidic chip and time-of-flight mass spectrometry J Dairy Sci, 2010. 93(9): p. 3940-9.

Froehlich, J.W., E.D. Dodds, M. Barboza, E.L. McJimpsey, R.R. Seipert, J. Francis, H.J. An, S. Freeman, J.B. German, and C.B. Lebrilla, Glycoprotein expression in human milk during lactation., 2010. 58(10): p. 6440-8.

Kronewitter, S.R., M.L. de Leoz, K.S. Peacock, K.R. McBride, H.J. An, S. Miyamoto, G.S. Leiserowitz, and C.B. Lebrilla, Human serum processing and analysis methods for rapid and reproducible N-glycan mass profiling. J Proteome Res, 2010. 9(10): p. 4952-9.

Lerno, L.A., Jr., J.B. German, and C.B. LebrillaMethod for the identification of lipid classes based on referenced Kendrick mass analysis. Anal Chem, 2010. 82(10): p. 4236-45.

Marcobal, A., M. Barboza, J.W. Froehlich, D.E. Block, J.B. German, C.B. Lebrilla, and D.A. Mills, Consumption of human milk oligosaccharides by gut-related microbes. J Agric Food Chem, 2010. 58(9): p. 5334-40.

Nwosu, C.C., J.S. Strum, H.J. An, and C.B. Lebrilla, Enhanced detection and identification of glycopeptides in negative ion mode mass spectrometry. Anal Chem, 2010. 82(23): p. 9654-62.

Tao, N., K.L. Ochonicky, J.B. German, S.M. Donovan, and C.B. Lebrilla, Structural determination and daily variations of porcine milk oligosaccharides. J Agric Food Chem, 2010. 58(8): p. 4653-9.

Wu, S., N. Tao, J.B. German, R. Grimm, and C.B. Lebrilla, Development of an annotated library of neutral human milk oligosaccharides. J Proteome Res, 2010. 9(8): p. 4138-51.

2011 Publications

An, H.J. and C.B. Lebrilla,Structure elucidation of native N- and O-linked glycans by tandem mass spectrometry (tutorial). Mass Spectrom Rev, 2011. 30(4): p. 560-78.

Chichlowski, M., J.B. German, C.B. Lebrilla, and D.A. Mills, The influence of milk oligosaccharides on microbiota of infants- opportunities for formulas.. Annu Rev Food Sci Technol, 2011. 2: p. 331-51.

Dallas, D.C., W.F. Martin, J.S. Strum, A.M. Zivkovic, J.T. Smilowitz, M.A. Underwood, M. Affolter, C.B. Lebrilla, and J.B. German, N-linked glycan profiling of mature human milk by high-performance microfluidic chip liquid chromatography time-of-flight tandem mass spectrometry. J Agric Food Chem, 2011. 59(8): p. 4255-63.

de Leoz, M.L., L.J. Young, H.J. An, S.R. Kronewitter, J. Kim, S. Miyamoto, A.D. Borowsky, H.K. Chew, and C.B. Lebrilla, High-mannose glycans are elevated during breast cancer progression. Mol Cell Proteomics, 2011. 10(1): p. M110 002717.

Froehlich, J.W., M. Barboza, C. Chu, L.A. Lerno, Jr., B.H. Clowers, A.M. Zivkovic, J.B. German, and C.B. Lebrilla, Nano-LC-MSMS of glycopeptides produced by nonspecific proteolysis enables rapid and extensive site-specific glycosylation determination. Anal Chem, 2011. 83(14): p. 5541-7.

Froehlich, J.W., C.S. Chu, N. Tang, K. Waddell, R. Grimm, and C.B. Lebrilla, Label-free liquid chromatography-tandem mass spectrometry analysis with automated phosphopeptide enrichment reveals dynamic human milk protein phosphorylation during lactation. Anal Biochem, 2011. 408(1): p. 136-46.

Hua, S., H.J. An, S. Ozcan, G.S. Ro, S. Soares, R. DeVere-White, and C.B. Lebrilla, Comprehensive native glycan profiling with isomer separation and quantitation for the discovery of cancer biomarkers. Analyst, 2011. 136(18): p. 3663-71.

Lee, H., H.J. An, L.A. Lerno, Jr., J.B. German, and C.B. Lebrilla, Rapid Profiling of Bovine and Human Milk Gangliosides by Matrix-Assisted Laser Desorption Ionization Fourier Transform Ion Cyclotron Resonance Mass Spectrometry Int J Mass Spectrom, 2011. 305(2-3): p. 138-150.

Li, B., S.C. Russell, J. Zhang, J.L. Hedrick, and C.B. Lebrilla, Structure determination by MALDI-IRMPD mass spectrometry and exoglycosidase digestions of O-linked oligosaccharides from Xenopus borealis egg jelly. Glycobiology, 2011. 21(7): p. 877-94.

Marcobal, A., M. Barboza, E.D. Sonnenburg, N. Pudlo, E.C. Martens, P. Desai, C.B. Lebrilla, B.C. Weimer, D.A. Mills, J.B. German, and J.L. Sonnenburg, Bacteroides in the Infant Gut Consume Milk Oligosaccharides via Mucus-Utilization Pathways Cell Host Microbe, 2011. 10(5): p. 507-14.

Nwosu, C.C., R.R. Seipert, J.S. Strum, S.S. Hua, H.J. An, A.M. Zivkovic, B.J. German, and C.B. Lebrilla, Simultaneous and extensive site-specific N- and O-glycosylation analysis in protein mixtures J Proteome Res, 2011. 10(5): p. 2612-24.

Sela, D.A., Y. Li, L. Lerno, S. Wu, A.M. Marcobal, J.B. German, X. Chen, C.B. Lebrilla, and D.A. Mills, An infant-associated bacterial commensal utilizes breast milk sialyloligosaccharides. J Biol Chem, 2011. 286(14): p. 11909-18.

Tao, N., S. Wu, J. Kim, H.J. An, K. Hinde, M.L. Power, P. Gagneux, J.B. German, and C.B. Lebrilla, Evolutionary glycomics- characterization of milk oligosaccharides in primates J Proteome Res, 2011. 10(4): p. 1548-57.

Wickramasinghe, S., S. Hua, G. Rincon, A. Islas-Trejo, J.B. German, C.B. Lebrilla, and J.F. Medrano, Transcriptome profiling of bovine milk oligosaccharide metabolism genes using RNA-sequencing. PLoS One, 2011. 6(4): p. e18895.

Wu, S., R. Grimm, J.B. German, and C.B. Lebrilla, Annotation and structural analysis of sialylated human milk oligosaccharides J Proteome Res, 2011. 10(2): p. 856-68.

Zivkovic, A.M., J.B. German, C.B. Lebrilla, and D.A. Mills, Human milk glycobiome and its impact on the infant gastrointestinal microbiota. Proc Natl Acad Sci U S A, 2011. 108 Suppl 1: p. 4653-8.

2012 Publications

Wu, S.; Salcedo, J.; Tang, N.; Waddell, K.; Grimm, R.; German, J. B.; Lebrilla, C. B., Employment of tandem mass spectrometry for the accurate and specific identification of oligosaccharide structures. Analytical chemistry 2012, 84 (17), 7456-62.

Vijayakumar, V.; Guerrero, A. N.; Davey, N.; Lebrilla, C. B.; Shields, D. C.; Khaldi, N., EnzymePredictor-a tool for predicting and visualizing enzymatic cleavages of digested proteins. Journal of proteome research 2012, 11 (12), 6056-65.

Vieira, A. C.; An, H. J.; Ozcan, S.; Kim, J. H.; Lebrilla, C. B.; Mannis, M. J.,Glycomic analysis of tear and saliva in ocular rosacea patients- the search for a biomarker. The ocular surface 2012, 10 (3), 184-92.

Totten, S. M.; Zivkovic, A. M.; Wu, S.; Ngyuen, U.; Freeman, S. L.; Ruhaak, L. R.; Darboe, M. K.; German, J. B.; Prentice, A. M.; Lebrilla, C. B., Comprehensive profiles of human milk oligosaccharides yield highly sensitive and specific markers for determining secretor status in lactating mothers. Journal of proteome research 2012, 11 (12), 6124-33.

Sundekilde, U. K.; Barile, D.; Meyrand, M.; Poulsen, N. A.; Larsen, L. B.; Lebrilla, C. B.; German, J. B.; Bertram, H. C.,Natural variability in bovine milk oligosaccharides from danish jersey and holstein-friesian breeds.Journal of agricultural and food chemistry 2012, 60 (24), 6188-96.

Strum, J. S.; Kim, J.; Wu, S.; De Leoz, M. L.; Peacock, K.; Grimm, R.; German, J. B.; Mills, D. A.; Lebrilla, C. B.,Identification and accurate quantitation of biological oligosaccharide mixtures. Analytical chemistry 2012, 84 (18), 7793-801.

Strum, J. S.; Aldredge, D.; Barile, D.; Lebrilla, C. B., Coupling flash liquid chromatography with mass spectrometry for enrichment and isolation of milk oligosaccharides for functional studies.Analytical biochemistry 2012, 424 (2), 87-96.

Sela, D. A.; Garrido, D.; Lerno, L.; Wu, S.; Tan, K.; Eom, H. J.; Joachimiak, A.; Lebrilla, C. B.; Mills, D. A., Bifidobacterium longum subsp. infantis ATCC 15697 α-fucosidases are active on fucosylated human milk oligosaccharides.Applied and environmental microbiology 2012, 78 (3), 795-803.

Ruhaak, L. R.; Miyamoto, S.; Kelly, K.; Lebrilla, C. B.,N-Glycan profiling of dried blood spots.Analytical chemistry 2012, 84 (1), 396-402.

Ruhaak, L. R.; Lebrilla, C. B., Advances in analysis of human milk oligosaccharides. Adv Nutr 2012, 3 (3), 406S-14S.

Ruhaak, L. R.; Lebrilla, C. B., Analysis and role of oligosaccharides in milk. BMB reports 2012, 45 (8), 442-51.

Nwosu, C. C.; Aldredge, D. L.; Lee, H.; Lerno, L. A.; Zivkovic, A. M.; German, J. B.; Lebrilla, C. B., Comparison of the human and bovine milk N-glycome via high-performance microfluidic chip liquid chromatography and tandem mass spectrometry. Journal of proteome research 2012, 11 (5), 2912-24.

Neville, M. C.; Anderson, S. M.; McManaman, J. L.; Badger, T. M.; Bunik, M.; Contractor, N.; Crume, T.; Dabelea, D.; Donovan, S. M.; Forman, N.; Frank, D. N.; Friedman, J. E.; German, J. B.; Goldman, A.; Hadsell, D.; Hambidge, M.; Hinde, K.; Horseman, N. D.; Hovey, R. C.; Janoff, E.; Krebs, N. F.; Lebrilla, C. B.; Lemay, D. G.; MacLean, P. S.; Meier, P.; Morrow, A. L.; Neu, J.; Nommsen-Rivers, L. A.; Raiten, D. J.; Rijnkels, M.; Seewaldt, V.; Shur, B. D.; VanHouten, J.; Williamson, P., Lactation and Neonatal Nutrition- Defining and Refining the Critical Questions. Journal of mammary gland biology and neoplasia 2012, 17 (2), 167-88.

Lee, H.; Lerno, L. A., Jr.; Choe, Y.; Chu, C. S.; Gillies, L. A.; Grimm, R.; Lebrilla, C. B.; German, J. B.,Multiple Precursor Ion Scanning of Gangliosides and Sulfatides with a Reverse-Phase Microfluidic Chip and Quadrupole Time-of-flight Mass Spectrometry.Analytical chemistry 2012, 84 (14), 5905-12.

Kronewitter, S. R.; De Leoz, M. L.; Strum, J. S.; An, H. J.; Dimapasoc, L. M.; Guerrero, A.; Miyamoto, S.; Lebrilla, C. B.; Leiserowitz, G. S., The glycolyzer- automated glycan annotation software for high performance mass spectrometry and its application to ovarian cancer glycan biomarker discovery. Proteomics 2012, 12 (15-16), 2523-38.

Hua, S.; Nwosu, C. C.; Strum, J. S.; Seipert, R. R.; An, H. J.; Zivkovic, A. M.; German, J. B.; Lebrilla, C. B., Site-specific protein glycosylation analysis with glycan isomer differentiation. Analytical and bioanalytical chemistry 2012, 403 (5), 1291-302.

Hernandez, M. R.; Towns, E. N.; Moore, J.; Lee, H.; German, J. B.; Lebrilla, C. B.; Parikh, A. N.; Land, D. P., Use of attenuated total reflectance Fourier transform infrared spectroscopy to study lactosylceramide and GD3 DMPC bilayersColloids and surfaces. B, Biointerfaces 2012, 94, 374-7.

Garrido, D.; Nwosu, C.; Ruiz-Moyano, S.; Aldredge, D.; German, J. B.; Lebrilla, C. B.; Mills, D. A., Endo-β-N-acetylglucosaminidases from infant-gut associated bifidobacteria release complex N-glycans from human milk glycoproteins.Molecular & cellular proteomics : MCP 2012, 11 (9), 775-85.

Faupel-Badger, J. M.; Arcaro, K. F.; Balkam, J. J.; Eliassen, A. H.; Hassiotou, F.; Lebrilla, C. B.; Michels, K. B.; Palmer, J. R.; Schedin, P.; Stuebe, A. M.; Watson, C. J.; Sherman, M. E., Postpartum remodeling, lactation, and breast cancer risk- summary of a national cancer institute-sponsored workshop.Journal of the National Cancer Institute 2012.

De Leoz, M. L.; Gaerlan, S. C.; Strum, J. S.; Dimapasoc, L. M.; Mirmiran, M.; Tancredi, D. J.; Smilowitz, J. T.; Kalanetra, K. M.; Mills, D. A.; German, J. B.; Lebrilla, C. B.; Underwood, M. A., Lacto-N-tetraose, fucosylation, and secretor status are highly variable in human milk oligosaccharides from women delivering preterm.Journal of proteome research 2012, 11 (9), 4662-72.

Bordiga, M.; Travaglia, F.; Meyrand, M.; German, J. B.; Lebrilla, C. B.; Coisson, J. D.; Arlorio, M.; Barile, D., Identification and characterization of complex bioactive oligosaccharides in white and red wine by a combination of mass spectrometry and gas chromatography. Journal of agricultural and food chemistry 2012, 60 (14), 3700-7.

Barboza, M.; Pinzon, J.; Wickramasinghe, S.; Froehlich, J. W.; Moeller, I.; Smilowitz, J. T.; Ruhaak, L. R.; Huang, J.; Lonnerdal, B.; German, J. B.; Medrano, J. F.; Weimer, B. C.; Lebrilla, C. B., Glycosylation of human milk lactoferrin exhibits dynamic changes during early lactation enhancing its role in pathogenic bacteria-host interactions. Molecular & cellular proteomics : MCP 2012, 11 (6), M111 015248.

An, H. J.; Gip, P.; Kim, J.; Wu, S.; Park, K. W.; McVaugh, C. T.; Schaffer, D. V.; Bertozzi, C. R.; Lebrilla, C. B.,Extensive determination of glycan heterogeneity reveals an unusual abundance of high mannose glycans in enriched plasma membranes of human embryonic stem cells. Molecular & cellular proteomics : MCP 2012, 11 (4), M111 010660.

Aldredge, D.; An, H. J.; Tang, N.; Waddell, K.; Lebrilla, C. B., Annotation of a serum N-glycan library for rapid identification of structures. Journal of proteome research 2012, 11 (3), 1958-68.

 

 

2013 Publications

Aldredge, D. L.; Geronimo, M. R.; Hua, S.; Nwosu, C. C.; Lebrilla, C. B.; Barile, D., Annotation and structural elucidation of bovine milk oligosaccharides and determination of novel fucosylated structures.Glycobiology 2013.

Bondoc, K.G., H. Lee, L.J. Cruz, C.B. Lebrilla, and M.A. Juinio-Menez, Chemical fingerprinting and phylogenetic mapping of saponin congeners from three tropical holothurian sea cucumbers. Comp Biochem Physiol B Biochem Mol Biol, 2013. 166(3-4): p. 182-93.

Dallas, D.C., A. Guerrero, N. Khaldi, P.A. Castillo, W.F. Martin, J.T. Smilowitz, C.L. Bevins, D. Barile, J.B. German, and C.B. Lebrilla, Extensive in vivo Human Milk Peptidomics Reveals Specific Proteolysis Yielding Protective Antimicrobial Peptides. J Proteome Res, 2013. 12(5): p. 2295-304.

De Leoz, M.L., C.B. Lebrilla, and M.A. Underwood, Response to Letter to the Editor regarding “A quantitative and comprehensive method to analyze human milk oligosaccharide structures in the urine and feces of infants”. Anal Bioanal Chem, 2013. 405(24): p. 7899-900.

De Leoz, M. L.; Wu, S.; Strum, J. S.; Ninonuevo, M. R.; Gaerlan, S. C.; Mirmiran, M.; German, J. B.; Mills, D. A.; Lebrilla, C. B.; Underwood, M. A.,A quantitative and comprehensive method to analyze human milk oligosaccharide structures in the urine and feces of infants. Analytical and bioanalytical chemistry 2013.

Faupel-Badger, J. M.; Arcaro, K. F.; Balkam, J. J.; Eliassen, A. H.; Hassiotou, F.; Lebrilla, C. B.; Michels, K. B.; Palmer, J. R.; Schedin, P.; Stuebe, A. M.; Watson, C. J.; Sherman, M. E., Postpartum remodeling, lactation, and breast cancer risk- summary of a national cancer institute-sponsored workshop.Journal of the National Cancer Institute 2013, 105, (3), 166-74.

Guerrero, A. and C.B. Lebrilla, New strategies for resolving oligosaccharide isomers by exploiting mechanistic and thermochemical aspects of fragment ion formation.Int J Mass Spectrom, 2013. 354-355.

Hong, Q., C.B. Lebrilla, S. Miyamoto, and L.R. Ruhaak, Absolute quantitation of Glyco-analytical multispecific proteolysis (Glyco-AMP) A simple method for detailed and quantitative glycoproteomic characterization.immunoglobulin G and its glycoforms using multiple reaction monitoring.  Anal Chem, 2013. 85(18): p. 8585-93.

Hua, S., C.Y. Hu, B.J. Kim, S.M. Totten, M.J. Oh, N. Yun, C.C. Nwosu, J.S. Yoo, C.B. Lebrilla, and H.J. An,Glyco-analytical multispecific proteolysis (Glyco-AMP) A simple method for detailed and quantitative glycoproteomic characterization. J Proteome Res, 2013. 12(10): p. 4414-23.

Hua, S.; Jeong, H. N.; Dimapasoc, L. M.; Kang, I.; Han, C.; Choi, J. S.; Lebrilla, C. B.; An, H. J., Isomer-Specific LCMS and LC-MSMS Profiling of the Mouse Serum N-Glycome Revealing a Number of Novel Sialylated N-Glycans. Analytical chemistry 2013.

Hua, S.; Williams, C. C.; Dimapasoc, L. M.; Ro, G. S.; Ozcan, S.; Miyamoto, S.; Lebrilla, C. B.; An, H. J.; Leiserowitz, G. S., Isomer-specific chromatographic profiling yields highly sensitive and specific potential N-glycan biomarkers for epithelial ovarian cancer. Journal of chromatography. A 2013, 1279, 58-67.

Kim, J. H.; An, H. J.; Garrido, D.; German, J. B.; Lebrilla, C. B.; Mills, D. A., Proteomic Analysis of Bifidobacterium longum subsp. infantis Reveals the Metabolic Insight on Consumption of Prebiotics and Host Glycans. PloS one 2013, 8, (2), e57535.

Lebrilla, C.B., Is high throughput glycomics possible? Mass Spectrometry 2013. 2: S0016.

Lee, H., J.B. German, R. Kjelden, C.B. Lebrilla, and D. Barile,Quantitative Analysis of Gangliosides in Bovine Milk and Colostrum-based Dairy Products by Ultra-high Performance Liquid Chromatography-Tandem Mass Spectrometry. J Agric Food Chem, 2013. 61(40): p. 9689-96.

Nwosu, C. C.; Huang, J.; Aldredge, D. L.; Strum, J. S.; Hua, S.; Seipert, R. R.; Lebrilla, C. B., In-gel nonspecific proteolysis for elucidating glycoproteins- a method for targeted protein-specific glycosylation analysis in complex protein mixtures.Analytical chemistry 2013, 85, (2), 956-63.

Ozcan, S.; An, H. J.; Vieira, A. C.; Park, G. W.; Kim, J. H.; Mannis, M. J.; Lebrilla, C. B., Characterization of Novel O-glycans isolated from Tear and Saliva of Ocular Rosacea PatientsJournal of proteome research 2013, 12, (3), 1090-100.

Ozcan, S., D.A. Barkauskas, L.R. Ruhaak, J. Javier Torres, C.L. Cooke, H. An, S. Hua, C.C. Williams, L.M. Dimapasoc, J. Kim, M. Camorlinga-Ponce, D.M. Rocke, C. Lebrilla, and J. Solnick, Serum glycan signatures of gastric cancer.. Cancer Prev Res (Phila), 2013.

Peacock, K.S., L.R. Ruhaak, M.K. Tsui, D.A. Mills, and C.B. Lebrilla, Isomer-Specific Isomer-Specific Consumption of Galactooligosaccharides by Bifidobacterial Species. J Agric Food Chem, 2013.

Ruhaak, L. R.; Miyamoto, S.; Lebrilla, C. B., Developments in the identification of glycan biomarkers for the detection of cancer. Molecular & cellular proteomics : MCP 2013.

Ruhaak, L.R., U.T. Nguyen, C. Stroble, S.L. Taylor, A. Taguchi, S.M. Hanash, C.B. Lebrilla, K. Kim, and S. Miyamoto, Enrichment strategies in glycomics-based lung cancer biomarker discovery Proteomics Clin Appl, 2013.

Ruhaak, L. R.; Taylor, S. L.; Miyamoto, S.; Kelly, K.; Leiserowitz, G. S.; Gandara, D.; Lebrilla, C. B.; Kim, K.,Chip-based nLC-TOF-MS is a highly stable technology for large-scale high-throughput analyses Analytical and bioanalytical chemistry 2013.

Ruiz-Moyano, S., S.M. Totten, D.A. Garrido, J.T. Smilowitz, J.B. German, C.B. Lebrilla, and D.A. Mills, Variation in consumption of human milk oligosaccharides by infant-gut associated strains of Bifidobacterium breve.Appl Environ Microbiol, 2013. 79(19): p. 6040-9.

Smilowitz, J.T., S.M. Totten, J. Huang, D. Grapov, H.A. Durham, C.J. Lammi-Keefe, C. Lebrilla, and J.B. German, Human Milk Secretory Immunoglobulin A and Lactoferrin N-Glycans Are Altered in Women with Gestational Diabetes Mellitus. J Nutr, 2013. 143(12): p. 1906-12.

Strum, J.S., C.C. Nwosu, S. Hua, S.R. Kronewitter, R.R. Seipert, R.J. Bachelor, H.J. An, and C.B. Lebrilla,Automated Assignments of N- and O-Site Specific Glycosylation with Extensive Glycan Heterogeneity of Glycoprotein Mixtures. Anal Chem, 2013.

New Site Launched

We’ve reinvigorated our site to make it easier to navigate and use. Frequent visitors to our site will find small changes in our URL structure, but everything is cleanly organized and easy to find.

Instruments: Agilent 6520

The Agilent 6520 series QTOF is used for proteomics, glycoproteomics, and glycomics studies. It uses high mass accuracy, reproducible retention times, and tandem mass spectrometry to qualitatively characterize samples and features an extended dynamic range to provide robust quantitation.

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