Validation of a glycan biomarker set for the detection of ovarian cancer using mass spectrometry

L. Renee Ruhaak1; Sandra Taylor1; Cynthia Williams1; UyenThao Nguyen1; Lauren Dimapasoc1; Sureyya Ozcan1; Carol Stroble1, 2; Suzanne Miyamoto2; Kyoungmi Kim1; Gary Leiserowitz2; Carlito B. Lebrilla1 1University of California, Davis, Davis, CA; 2UC Davis Comprehensive Cancer Center, Sacramento, CA NOVEL ASPECT: Altered serum glycan profiles were validated as discriminating OC cases from controls, showing its great potential as a diagnostic tool. […]
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May, 21, 2013
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Rapid Throughput Extraction of Human Milk Oligosaccharides to Allow Studies on Larger Cohorts

Lauren M. Dimapasoc; Sarah Totten; Carol Stroble; L. Renee Ruhaak; Carlito B. Lebrilla University of California, Davis, CA NOVEL ASPECT: HMO extraction and purification at the 96-well level now allows for large-scale biomarker studies. INTRODUCTION: Human milk is known to be the best nutritional source for newborns. Human milk oligosaccharides (HMOs) are a highly abundant constituent in human milk, […]
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May, 21, 2013
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Congratulations!
Carlito Lebrilla is elected to the board of US HUPO. See the news here! http://www.ushupo.org/Portals/0/Board/PRESS%20RELEASE%20April%202013.pdf Congrats to Renee Ruhaak for being selected for a Agilent Travel award for the upcoming ASMS conference! http://www.chem.agilent.com/en-US/promotions/Pages/SteveBergerAward.aspx
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May, 02, 2013
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New paper!
Dallas, D. C., et al. (2013). “Extensive in vivo human milk peptidomics reveals specific proteolysis yielding protective antimicrobial peptides.” J Proteome Res. Milk is traditionally considered an ideal source of the basic elemental nutrients required by infants. More detailed examination is revealing that milk represents a more functional ensemble of components with benefits to both […]
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Apr, 24, 2013
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1997 Publications
Green, M.K. and C.B. Lebrilla, Ion-molecule reactions as probes of gas-phase structures of peptides and proteins. Mass Spectrom Rev, 1997. 16(2): p. 53-71. Hu, H., S.G. Penn, C.B. Lebrilla, and P.H. Brown, Isolation and characterization of soluble boron complexes in higher plants. The mechanism of phloem mobility of boron.. The mechanism of phloem mobility of […]
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Jan, 29, 2013
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1988 Publications
Pruesse, T., C.B. Lebrilla, T. Drewello, and H. Schwarz, Iron(I)-induced demethanation of tert-butyl-substituted nitriles in the gas phase. A case of remote functionalization of carbon-carbon bonds.. J Am Chem Soc, 1988. 110(18): p. 5986-93.
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Jan, 28, 2013
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1990 Publications
Lebrilla, C.B., D.T. Wang, R.L. Hunter, and R.T. McIver, Jr., Detection of mass 31,830 ions with an external ion source Fourier transform mass spectrometer.. Anal Chem, 1990. 62(8): p. 878-80.
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Jan, 28, 2013
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1993 Publications
Carroll, J.A., L. Ngoka, C.G. Beggs, and C.B. Lebrilla, Liquid secondary ion mass spectrometry Fourier transform mass spectrometry of oligosaccharide anions.. Anal Chem, 1993. 65(11): p. 1582-7.
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Jan, 28, 2013
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1994 Publications
1. Ngoka, L. C.; Gal, J. F.; Lebrilla, C. B., Effects of cations and charge types on the metastable decay rates of oligosaccharides.. Analytical chemistry 1994, 66 (5), 692-8.
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Jan, 28, 2013
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1995 Publications
1. Wu, J.; Fannin, S. T.; Franklin, M. A.; Molinski, T. F.; Lebrilla, C. B., Exact mass determination for elemental analysis of ions produced by matrix-assisted laser desorption.. Analytical chemistry 1995, 67 (20), 3788-92.
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Jan, 28, 2013
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